Elane Bennis

Neutrophil elastase (ec 3.4.21.37, leukocyte elastase, elane, ela2, elastase 2, neutrophil, elaszym, serine elastase, subtype human leukocyte elastase (hle)) is a serine proteinase in the same family. Jan 23, 2014in one, elane mutations lead to mislocalization of ne. In the other, elane mutations disturb protein folding, inducing an unfolded protein response in the endoplasmic reticulum (er).

The elane gene provides instructions for making a protein called neutrophil elastase. Nov 13, 2025elane (elastase, neutrophil expressed) is a protein coding gene. Diseases associated with elane include cyclic neutropenia and neutropenia, severe congenital, 1, autosomal dominant.

Intriguingly, elane can not only selectively induce cell death in diverse cancer cells, but not in normal cells, through liberating the cd95 death domain (dd) that interacts with histone h1 . Explore the elane gene, its role in neutrophil elastase production, and the implications of mutations for various diseases. Aug 2, 2025the elane gene provides instructions for making a protein called neutrophil elastase.

Oct 1, 2021the formation of the h1-dd elane complex may mediate reactive oxygen species at mitochondria and play a vital role in the anticancer selectivity of elane Apr 9, 2025neutrophil elastase (elane) is upregulated in metabolic-associated fatty liver disease (mafld) and has the capacity to promote disease progression.