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Here are two diseases that are easy to confuse: Both diseases are characterized by bullae (big, blister-like skin lesions) and both have. Jun 7, 2025pemphigus vulgaris and bullous pemphigoid are distinct autoimmune blistering skin diseases with important differences in their clinical presentation, pathophysiology, and.

Therefore, dif must be used to distinguish between these 2 diseases. Pemphigus vulgaris and bullous pemphigoid are both autoimmune skin disorders, but they differ in several ways.